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Regulation of transposable elements by DNA modifications
Maintenance of genome stability requires control over the expression of transposable elements (TEs), whose activity can have substantial deleterious effects on the host. Chemical modification of DNAExpand
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TET-dependent regulation of retrotransposable elements in mouse embryonic stem cells
BackgroundTen-eleven translocation (TET) enzymes oxidise DNA methylation as part of an active demethylation pathway. Despite extensive research into the role of TETs in genome regulation, little isExpand
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Functional evaluation of transposable elements as enhancers in mouse embryonic and trophoblast stem cells
Transposable elements (TEs) are thought to have helped establish gene regulatory networks. Both the embryonic and extraembryonic lineages of the early mouse embryo have seemingly co-opted TEs asExpand
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TET2 Regulates the Neuroinflammatory Response in Microglia.
Epigenomic mechanisms regulate distinct aspects of the inflammatory response in immune cells. Despite the central role for microglia in neuroinflammation and neurodegeneration, little is known aboutExpand
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SETDB1 prevents TET2-dependent activation of IAP retroelements in naïve embryonic stem cells
BackgroundEndogenous retroviruses (ERVs), which are responsible for 10% of spontaneous mouse mutations, are kept under control via several epigenetic mechanisms. The H3K9 histone methyltransferaseExpand
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Author Correction: Regulation of transposable elements by DNA modifications
The originally published article contained an error in Figure 2a: for the left side of the figure part (showing piRNA-directed DNA methylation of mouse transposable elements), DNMT3A/B should haveExpand
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TET2 regulates the neuroinflammatory response in microglia
Epigenetic mechanisms regulate distinct aspects of the inflammatory response in various immune cell types. Despite the central role for microglia, the resident macrophages of the brain, inExpand
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SETDB1 prevents TET2-dependent activation of IAP retroelements in naïve embryonic stem cells
Background Endogenous retroviruses (ERVs), which are responsible for 10% of spontaneous mouse mutations, are kept under control via several epigenetic mechanisms. The H3K9 histone methyltransferaseExpand
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Functional evaluation of transposable elements as transcriptional enhancers in mouse embryonic and trophoblast stem cells
The recurrent invasion and expansion of transposable elements (TEs) throughout evolution brought with it a vast array of coding and non-coding sequences that can serve as substrates for naturalExpand