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BACKGROUND An increase in the incidence and severity of Clostridium difficile-associated disease in Québec and the United States has been associated with a hypervirulent strain referred to as North American pulsed-field type 1 (NAP1)/027. METHODS In 2005, a prospective study was conducted in 88 Québec hospitals, and 478 consecutive nosocomial isolates of(More)
et al. Isolation of Rickettsia parkeri and identifi cation of a novel spotted fever group Rickettsia sp. from Gulf Coast ticks (Amblyomma maculatum) in the rates of Rickettsia parkeri infection in Gulf Coast ticks (Amblyomma maculatum) and identifi cation of " Candidatus Rickettsia andeanae " from Fairfax County, Virginia. A ten-year study of tick biting in(More)
CONTEXT Persons with cytomegalovirus (CMV) retinitis and acquired immunodeficiency syndrome (AIDS) have required lifelong anti-CMV therapy to prevent the progression of retinal disease and subsequent loss of vision. OBJECTIVE To determine whether patients who were taking highly active antiretroviral therapy (HAART) and who had stable CMV retinitis could(More)
Linomide is a potent immunomodulator that either enhances or suppresses certain immunological processes. Of particular interest is this compound's capacity to inhibit a variety of organ-specific autoimmune diseases. Here, we report on the effects of linomide on several immunological reactions elicited by endotoxin (LPS), both in vivo and in vitro. In rats(More)
To evaluate the safety and potential therapeutic activity of humanized anti-IL-2 receptor mAb (Daclizumab) therapy in the treatment of patients with severe, sight-threatening, intermediate and posterior noninfectious uveitis, a nonrandomized, open-label, pilot study was performed. Patients with uveitis were treated with a minimum of 20 mg of prednisone,(More)
OBJECTIVE To explore epidemiological patterns of the incidence of Clostridium difficile infection (CDI) and hospital characteristics associated with increased incidence during nonepidemic and epidemic years. DESIGN Retrospective and prospective ecological study. SETTING Eighty-three acute care hospitals participating in CDI surveillance in the province(More)
BACKGROUND In Canada, a pneumococcal conjugate vaccine was licensed in 2001, and in the province of Quebec, a publicly-funded program was implemented for high-risk children in 2002, using a 4-dose schedule, and for all children in 2004, using a 3-dose schedule. OBJECTIVES To describe the epidemiology of hospitalized pneumonia in the population aged <5(More)
BACKGROUND The burden of central line-associated bloodstream infections (CLABSI) in Canadian intensive care units (ICUs) is not well established. The present study aimed to describe CLABSI epidemiology in Quebec ICUs during 2003-2009. METHODS The study population was a retrospective dynamic cohort of 58 ICUs that participated in the Surveillance(More)