Author pages are created from data sourced from our academic publisher partnerships and public sources.
Share This Author
Brain fuel metabolism, aging, and Alzheimer's disease.
Lower brain glucose metabolism is present before the onset of clinically measurable cognitive decline in two groups of people at risk of Alzheimer's disease--carriers of apolipoprotein E4, and in… Expand
Can Ketones Help Rescue Brain Fuel Supply in Later Life? Implications for Cognitive Health during Aging and the Treatment of Alzheimer’s Disease
- S. Cunnane, A. Courchesne-Loyer, +7 authors C. Castellano
- Psychology, Medicine
- Front. Mol. Neurosci.
- 8 July 2016
We propose that brain energy deficit is an important pre-symptomatic feature of Alzheimer’s disease (AD) that requires closer attention in the development of AD therapeutics. Our rationale is… Expand
Image-derived input function in dynamic human PET/CT: methodology and validation with 11C-acetate and 18F-fluorothioheptadecanoic acid in muscle and 18F-fluorodeoxyglucose in brain
- É. Croteau, É. Lavallée, +7 authors F. Bénard
- European Journal of Nuclear Medicine and…
- 2 May 2010
PurposeDespite current advances in PET/CT systems, blood sampling still remains the standard method to obtain the radiotracer input function for tracer kinetic modelling. The purpose of this study… Expand
Can ketones compensate for deteriorating brain glucose uptake during aging? Implications for the risk and treatment of Alzheimer's disease
- S. Cunnane, A. Courchesne-Loyer, +5 authors C. Castellano
- Annals of the New York Academy of Sciences
- 1 March 2016
Brain glucose uptake is impaired in Alzheimer's disease (AD). A key question is whether cognitive decline can be delayed if this brain energy defect is at least partly corrected or bypassed early in… Expand
Abnormal in vivo myocardial energy substrate uptake in diet-induced type 2 diabetic cardiomyopathy in rats.
- S. Ménard, É. Croteau, +8 authors A. Carpentier
- Biology, Medicine
- American journal of physiology. Endocrinology and…
- 1 May 2010
The purpose of this study was to determine in vivo myocardial energy metabolism and function in a nutritional model of type 2 diabetes. Wistar rats rendered insulin-resistant and mildly… Expand
A ketogenic drink improves brain energy and some measures of cognition in mild cognitive impairment
- M. Fortier, C. Castellano, É. Croteau, F. Langlois, S. Cunnane
- Alzheimer's & Dementia
- 1 May 2019
Unlike for glucose, uptake of the brain's main alternative fuel, ketones, remains normal in mild cognitive impairment (MCI). Ketogenic medium chain triglycerides (kMCTs) could improve cognition in… Expand
Ketogenic Medium Chain Triglycerides Increase Brain Energy Metabolism in Alzheimer's Disease.
- É. Croteau, C. Castellano, +9 authors S. Cunnane
- Chemistry, Medicine
- Journal of Alzheimer's disease : JAD
BACKGROUND In Alzheimer's disease (AD), it is unknown whether the brain can utilize additional ketones as fuel when they are derived from a medium chain triglyceride (MCT) supplement. OBJECTIVE To… Expand
Quantitative myocardial perfusion and coronary reserve in rats with 13N-ammonia and small animal PET: impact of anesthesia and pharmacologic stress agents.
- É. Croteau, F. Bénard, M. Bentourkia, J. Rousseau, M. Paquette, R. Lecomte
- Journal of nuclear medicine : official…
- 1 November 2004
UNLABELLED The purpose of this study was to evaluate the effects of 2 anesthetic agents on myocardial perfusion and coronary reserve in rats under resting and stress conditions with small animal PET.… Expand
A Small Animal Positron Emission Tomography Study of the Effect of Chemotherapy and Hormonal Therapy on the Uptake of 2-Deoxy-2-[F-18]fluoro-d-glucose in Murine Models of Breast Cancer
PurposeWe used small animal positron emission tomography (PET) imaging to monitor the time-course of tumor metabolic response to hormone and chemotherapy in a murine model of hormone-sensitive breast… Expand
Conversion of arterial input functions for dual pharmacokinetic modeling using Gd‐DTPA/MRI and 18F‐FDG/PET
Reaching the full potential of magnetic resonance imaging (MRI)‐positron emission tomography (PET) dual modality systems requires new methodologies in quantitative image analyses. In this study,… Expand