• Publications
  • Influence
Abstract The complexes of hexanedioic acid bis(3-hydroxycarbamoyl-methyl)amide (Dha1) and hexanedioic acid bis(3-hydroxycarbamoyl-propyl)amide (Dha2) with cobalt(II), nickel(II), copper(II),Expand
  • 101
  • 6
Interaction of Triapine and related thiosemicarbazones with iron(III)/(II) and gallium(III): a comparative solution equilibrium study.
Stoichiometry and stability of Ga(III), Fe(III), Fe(II) complexes of Triapine and five related α-N heterocyclic thiosemicarbazones with potential antitumor activity have been determined byExpand
  • 52
  • 3
  • PDF
Comparative Solution Equilibrium Study of the Interactions of Copper(II), Iron(II) and Zinc(II) with Triapine (3‐Aminopyridine‐2‐carbaldehyde Thiosemicarbazone) and Related Ligands
The interactions of Cu II ,Z n II and Fe II with Triapine (3-aminopyridine-2-carbaldehyde thiosemicarbazone), which is currently undergoing phase II clinical trials as a chemotherapeutic antitumourExpand
  • 53
  • 2
Pteridine-sulfonamide conjugates as dual inhibitors of carbonic anhydrases and dihydrofolate reductase with potential antitumor activity.
Recent evidences suggest that cancer treatment based on combination of cytostatic and conventional chemostatic therapeutics, which are usually cytotoxic, can provide an improved curative option. OnExpand
  • 39
  • 2
  • PDF
Methotrexate γ-hydroxamate derivatives as potential dual target antitumor drugs
A series of new aminopteroyl-based hydroxamate derivatives were synthesized and tested in vitro in cell culture models as potential dual target drugs. These compounds were designed to target twoExpand
  • 20
  • 2
Biospeciation of antidiabetic VO(IV) complexes
Abstract The possible transformations of antidiabetic vanadium(IV) complexes in the organism are discussed. These reactions involve absorption processes in the gastrointestinal tract, transport inExpand
  • 124
  • 1
Characterization of the binding sites of the anticancer ruthenium(III) complexes KP1019 and KP1339 on human serum albumin via competition studies
Indazolium trans-[tetrachloridobis(1H-indazole)ruthenate(III)] (KP1019) and its Na+ analogue (KP1339) are two of the most prominent non-platinum antitumor metal complexes currently undergoingExpand
  • 92
  • 1
  • PDF
Ribonucleotide reductase inhibition by metal complexes of Triapine (3-aminopyridine-2-carboxaldehyde thiosemicarbazone): a combined experimental and theoretical study.
Triapine (3-aminopyridine-2-carboxaldehyde thiosemicarbazone, 3-AP) is currently the most promising chemotherapeutic compound among the class of α-N-heterocyclic thiosemicarbazones. Here we reportExpand
  • 75
  • 1
Oral administration of a zinc complex improves type 2 diabetes and metabolic syndromes.
Previously, we reported that intraperitoneal injections of the Zn(II) complex (Zn(alx)(2)) with allixin, which is isolated from dry garlic, with a Zn(O(4)) coordination environment, exhibited highExpand
  • 86
  • 1
Copper(ii) thiosemicarbazone complexes induce marked ROS accumulation and promote nrf2-mediated antioxidant response in highly resistant breast cancer cells.
A series of water-soluble sodium salts of 3-formyl-4-hydroxybenzenesulfonic acid thiosemicarbazones (or sodium 5-sulfonate-salicylaldehyde thiosemicarbazones) containing different substituents at theExpand
  • 34
  • 1
  • PDF