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A COMPARISON BETWEEN THE CHELATING PROPERTIES OF SOME DIHYDROXAMIC ACIDS, DESFERRIOXAMINE B AND ACETOHYDROXAMIC ACID
Ribonucleotide reductase inhibition by metal complexes of Triapine (3-aminopyridine-2-carboxaldehyde thiosemicarbazone): a combined experimental and theoretical study.
Interaction of Triapine and related thiosemicarbazones with iron(III)/(II) and gallium(III): a comparative solution equilibrium study.
- É. A. Enyedy, M. Primik, C. Kowol, V. Arion, T. Kiss, B. Keppler
- ChemistryDalton transactions
- 14 June 2011
The results show that among the thiosemicarbazones with various substituents the N-terminal dimethylation does not exert a measurable effect on the redox potential, but has the highest impact on the stability of the complexes as well as the cytotoxicity.
Biospeciation of antidiabetic VO(IV) complexes
Comparative Solution Equilibrium Study of the Interactions of Copper(II), Iron(II) and Zinc(II) with Triapine (3‐Aminopyridine‐2‐carbaldehyde Thiosemicarbazone) and Related Ligands
The interactions of Cu II ,Z n II and Fe II with Triapine (3-aminopyridine-2-carbaldehyde thiosemicarbazone), which is currently undergoing phase II clinical trials as a chemotherapeutic antitumour…
Thiomaltol-Based Organometallic Complexes with 1-Methylimidazole as Leaving Group: Synthesis, Stability, and Biological Behavior.
Thiomaltol, a potential S,O-coordinating molecule, has been utilized for the complexation of four different organometallic fragments, yielding the desired RuII , OsII , RhIII , and IrIII complexes…
Methotrexate γ-hydroxamate derivatives as potential dual target antitumor drugs
Cancer Cell Resistance Against the Clinically Investigated Thiosemicarbazone COTI-2 Is Based on Formation of Intracellular Copper Complex Glutathione Adducts and ABCC1-Mediated Efflux
Only thiosemicarbazones forming stable, nonreducible copper(II)-glutathione adducts are recognized and, in turn, effluxed by ABCC1, revealing a crucial connection between copper complex chemistry, glutathione interaction, and the resistance profile of clinically relevant thiosesmicarbzones.
Characterization of the binding sites of the anticancer ruthenium(III) complexes KP1019 and KP1339 on human serum albumin via competition studies
- O. Dömötör, C. Hartinger, Anna K. Bytzek, T. Kiss, B. Keppler, É. A. Enyedy
- Chemistry, BiologyJBIC Journal of Biological Inorganic Chemistry
Conditional stability constants for the binding of KP1019 and KP1339 to sites I and II of HSA were determined, indicating that both Ru(III) compounds bind to both sites with moderately strong affinity.
Copper(ii) thiosemicarbazone complexes induce marked ROS accumulation and promote nrf2-mediated antioxidant response in highly resistant breast cancer cells.
The copper(ii) complexes showed moderate anticancer activity in established human cancer cell lines, while the proligands were devoid of cytotoxicity.