É. Sh. Matlina

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A study was made of the effects of prenatal stress on the reactivity of the hypothalamic-pituitary adrenal (HPA) axis in male and female offspring. Rat dams were subjected to noise and light stress on an unpredictable basis throughout pregnancy. At 28 days of age mRNA for POMC, proenkephalin and prodynorphin were measured in the hypothalamus of the(More)
The effect of adrenocortical hormones on catecholamine synthesis in the adrenals and heart of rats was studied after prolonged swimming (8 h). Catecholamine synthesis during incubation of the adrenals with L-tyrosine was sharply depressed after swimming. Addition of hydrocortisone or prednisolone in vitro (50 μg per sample) and also injection of these(More)
An inquiry was made into the time correlation of changes occurring in the muscular power with humoral shifts (adrenalin-like substances, pseudo and true cholinesterase) in myasthenia patients subjected to the administration of anticholinesterase preparations: briefly acting proserin and oxamysil — a preparation with a prolonged effect. There was no complete(More)
The majority of the studies on the significance of neurohumoral factors in the pathogenesis of myasthenia were limited to the ascertaining of the role played by acetylcholine. This work was devoted to the other mediator factor — adrenalin and adrenalin-like substances. An association was demonstrated between the shifts of the adrenalin-like substances and(More)
1. T .A . Korolenko and V. G. Titova, Byull. ]~ksp. Biol. Med., No. 7, 816 (1976). 2. A .A. Pokrovskii and V. A. Tutel'yan, Lysosmes [in Russian], Moscow {1976). 3. L D. Algranati and D. D. Sabatini, Btochem. Biophys. Res. Commun., 90, 220 (1979). 4. A . J . Barrett , in: Lysosomes: A Laboratory Handbook, J. T. Dingle, ed., North-Holland, Amsterdam (1972).(More)
The ability of the adrenals to synthesize catecholamines in the presence of various substrates was investigated in vitro. Experiments were carried out on rats under normal conditions and after swimming for 8 h. In the physically fatigued animals the conversion of noradrenalin, DOPA, and tyrosine, added in vitro, into catecholamines was inhibited, on the(More)