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Molecular model of hemoglobin N from Mycobacterium tuberculosis bound to lipid bilayers: a combined spectroscopic and computational study.
The interactions between hemoglobin N (HbN), a group I 2-on-2 hemoglobin from the pathogenic Mycobacterium tuberculosis (Mtb), and biological membranes using both experimental techniques and MD simulations indicated that HbN is a peripheral protein, and the association with the membranes occurred via the pre-A, G, and H helices. Expand
Dye-release assay for investigation of antimicrobial peptide activity in a competitive lipid environment
The results support the general conclusion that AMP have greater affinity for negatively charged membranes, for example bacterial membranes, than for the neutral membrane surface found in eukaryotic cells, but only within a competitive lipid environment. Expand
Study of the Interactions Between Model Membranes and a Truncated Hemoglobin (trHbN) by NMR and Infrared Spectroscopy
Approximately one third of the world population is infected by the pathogenic bacterium Mycobacterium tuberculosis. A key to the resilience of M. tuberculosis resides in part in its capacity to enterExpand