Çiğdem Özer

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Leptin produces effects in central nervous system and peripheral tissues via its specific receptors. Leptin also stimulates nitric oxide release in a concentration-dependent manner. In this study, our aim was to test the hypothesis that whether leptin has a modulatory role on endothelium or smooth muscle function in streptozotocin (STZ)-induced diabetic(More)
Transforming growth factor (TGF) α accelerates wound healing, especially in gastric ulcers. Transforming growth factor α can be affected by acid and pepsin in the gastric juice. Oxidative stress also plays a role in the formation of gastric lesions. This study was designed (1) to investigate the effects of microemulsion dosage form on the healing of gastric(More)
The aim of this study was to develop and characterize rh- IL-2 loaded chitosan-based nanogels for the healing of wound incision in rats. Nanogels were prepared using chitosan and bovine serum albumin (BSA) by ionic gelation method and high temperature application, respectively. Particle size, zeta potential, and polydispersity index were measured for(More)
Tryptophan as a circulating precursor of serotonin (5-HT) may suppress food intake and body weight. Tryptophan administration can enhance the generation of reactive oxygen species (ROS) by inducing oxidative pathway in vivo and in vitro. We have examined the effect of repeated tryptophan administration on food consumption, body weight, brain lipid(More)
Spontaneous, isolated focal renal artery dissection is an extremely rare cause of renovascular hypertension. Imaging technology for the renal arteries has evolved recently with the development of multidetector computed tomography angiography (CTA), and intravascular ultrasound. We describe a 52-year-old man with spontaneous renal artery dissection(More)
In this study, we investigated the effect of leptin on caspase-3, caspase-8, and caspase-9 immunoreactivity and lipid peroxidation in the stomachs of rats exposed to cold-restraint stress. Thirty-two male Wistar Albino rats were used. Rats pretreated with leptin (10 µg/kg per day for 7 days) were restrained in a wire cage for 4 h at 4°C. Spectrophotometric(More)
Increased oxidant stress plays an important role in the etiopathogenesis of chronic complications of diabetes. This study aimed to examine the effects of ascorbic acid (vitamin C, AA) supplementation on the oxidant and antioxidant processes in the brain of diabetic rats. Wistar albino rats were divided into four groups: group 1 (control), group 2 (ascorbic(More)
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