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Beneficial effects of metoprolol in idiopathic dilated cardiomyopathy
In patients with idiopathic dilated cardiomyopathy, treatment with metoprolol prevented clinical deterioration, improved symptoms and cardiac function, and was well tolerated. Expand
A novel polymorphism in the gene coding for the beta(1)-adrenergic receptor associated with survival in patients with heart failure.
- M. Börjesson, Y. Magnusson, Å. Hjalmarson, B. Andersson
- European heart journal
- 1 November 2000
It is suggested that the beta(1)-receptor Ser49Gly variant might be associated with altered receptor function, resulting in myocardial protection in patients with heart failure, and associated with a decreased mortality risk in Patients with congestive heart failure. Expand
EFFECT ON MORTALITY OF METOPROLOL IN ACUTE MYOCARDIAL INFARCTION A Double-blind Randomised Trial
The effect of metoprolol on mortality was compared with that of placebo in a double blind randomised trial in patients with definite or suspected acute myocardial infarction and there was a reduction of 36% (p less than 0.03). Expand
Effect of chronic beta-adrenergic receptor blockade in congestive cardiomyopathy.
It is indicated that adrenergic beta-blocking agents can improve heart function in at lease some patients with congestive cardiomyopathy and suggested that increased catecholamine activity may be an important factor for the development of this disease. Expand
Patients admitted to the emergency room with symptoms indicative of acute myocardial infarction
- B. Karlson, J. Herlitz, P. Pettersson, H. Ekvall, Å. Hjalmarson
- Journal of internal medicine
- 1 September 1991
It is concluded that few of the patients had an obvious infarction on admission, and that a musculoskeletal origin of the symptoms occurred most frequently in patients with no suspected infarctions. Expand
Female sex is associated with increased mortality and morbidity early, but not late, after coronary artery bypass grafting.
- G. Brandrup-Wognsen, H. Berggren, M. Hartford, Å. Hjalmarson, T. Karlsson, J. Herlitz
- European heart journal
- 1 September 1996
Females run an increased risk of early death and the development of postoperative complications after coronary artery bypass surgery as compared with males and late mortality does not appear to be influenced by gender and the long-term benefit of the coronary arteries bypass graft operation is similar in men and women. Expand
Autoimmunity in idiopathic dilated cardiomyopathy. Characterization of antibodies against the beta 1-adrenoceptor with positive chronotropic effect.
The second extracellular loop of the beta 1-adrenoceptor is a specific target for antibodies with stimulatory activity detected in patients with idiopathic DCM and the antibodies have a positive chronotropic effect on isolated rat heart myocytes. Expand
Metoprolol-induced reduction in postinfarction mortality: pooled results from five double-blind randomized trials.
It is concluded that metoprolol therapy after acute myocardial infarction reduces the total number of deaths, and especially sudden cardiac deaths. Expand
Effects of metoprolol on mortality and late infarction in diabetics with suspected acute myocardial infarction. Retrospective data from two large studies.
From two large scale studies in patients with suspected acute myocardial infarction and the MIAMI Trial, the effect of metoprolol on mortality appears particularly impressive in diabetics. Expand
Effects of beta blockade on sudden cardiac death during acute myocardial infarction and the postinfarction period.
- Å. Hjalmarson
- The American journal of cardiology
- 13 November 1997
It has been proposed that beta blockers with a high degree of lipophilicity penetrate the brain and thereby maintain high vagal tone during stress and a combination of direct anti-ischemic effects due to beta1 blockade and preservation of vagaltone appears to prevent VF in these animal models. Expand