Áron Kerenyi

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Introduction:The precise temperature for optimal neuroprotection in infants with neonatal encephalopathy is unclear. Our aim was to assess systemic effects of whole-body cooling to 35 °C, 33.5 °C, and 30 °C in a piglet model of perinatal asphyxia.Methods:Twenty–eight anesthetized male piglets aged <24 h underwent hypoxia–ischemia (HI) and were randomized to(More)
BACKGROUND AND PURPOSE In infants with moderate to severe neonatal encephalopathy, whole-body cooling at 33°C to 34°C for 72 hours is standard care with a number needed to treat to prevent a adverse outcome of 6 to 7. The precise brain temperature providing optimal neuroprotection is unknown. METHODS After a quantified global cerebral hypoxic-ischemic(More)
The precise temperature for optimal neuroprotection in infants with neonatal encephalopathy is unclear. Our aim was to assess systemic effects of whole-body cooling to 35°C, 33.5°C and 30°C in a piglet perinatal asphyxia model. Twenty-eight anesthetised male piglets aged <24h underwent hypoxia-ischemia and randomized to normothermia; or cooling to rectal(More)
Hypothermia can reduce neurodevelopmental disabilities in asphyxiated newborn infants. However, the optimal cooling temperature for neuroprotection is not well defined. We studied the effects of transient piglet brain hypoxic ischemia (HI) on transcriptional activity of eight genes and if mRNA level alterations could be counteracted by whole body cooling to(More)
Therapeutic hypothermia is now standard clinical care for moderate to severe neonatal encephalopathy in the United Kingdom and developed world. Clinical trials have included whole-body cooling with core temperature reduced to 33.5°C for 72 hours because the optimal temperature for neural rescue is likely to be below 34°C. There are, however, 40–50% of(More)
Inflammatory cytokines are implicated in the pathogenesis of perinatal hypoxia-ischemia (HI). The influence of hypothermia (HT) on cytokines after HI is unclear. Our aim was to assess in a piglet asphyxia model, under normothermic (NT) and HT conditions: (i) the evolution of serum cytokines over 48 h and (ii) cerebrospinal fluid (CSF) cytokine levels at 48(More)
Background: Therapeutic hypothermia reduces morbidity and mortality in infants with neonatal encephalopathy. Clinical trials are investigating lower temperatures as tailoring cooling with precision may provide benefit.Aims: To assess systemic effects of whole body cooling to 35oC, 33.5oC and 30oC in piglet model of perinatal asphyxia.Methods: Twenty eight(More)
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