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Recent experimental observations of spike-timing-dependent synaptic plasticity (STDP) have revitalized the study of synaptic learning rules. The most surprising aspect of these experiments lies in the observation that synapses activated shortly after the occurrence of a postsynaptic spike are weakened. Thus, synaptic plasticity is sensitive to the temporal(More)
Burst "ring is a prominent feature of cortical pyramidal cells and is thought to have signi"cant functional roles in reliable signaling and synaptic plasticity. Modeling studies have successfully elucidated possible biophysical mechanisms underlying complex bursting in pyr-amidal cells. Based on these results (Pinsky, Rinzel, J. Comput. Neurosci. 1 (1994)(More)
Brief, high-frequency bursts are commonly observed in neuronal recordings and are thought to represent a special neural code. Bursts have variable durations and spike counts which can encode stimulus variables. Here we examine how a burst duration code can be read out by synapses with short-term dynamics. We ÿnd that synapses can be tuned to preferentially(More)
Recent experimental evidence suggests that inhibitory synapses are associated with di!erent actions depending upon their location (Miles et al., Neuron 16 (1996) 815}823). We investigated that question of whether this e!ect is due to di!erent subspecies of GABA receptors giving rise to distinct responses (Pearce, Neuron 10 (1993) 189}20) or cable "ltering(More)
Decision confidence is a forecast about the probability that a decision will be correct. From a statistical perspective, decision confidence can be defined as the Bayesian posterior probability that the chosen option is correct based on the evidence contributing to it. Here, we used this formal definition as a starting point to develop a normative(More)
Single cell and population activities in the olfactory bulb and the hippocampus Synopsis Dynamics of single cells and large cell populations are the subject of investigation by using differently detailed models. Multicompartmental modeling techniques are used to systematically investigate the location-dependent effects of GABA-ergic dendritic inhibition on(More)