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Protecting groups for RNA synthesis: an increasing need for selective preparative methods.
- Á. Somoza
- Chemistry, BiologyChemical Society reviews
- 1 December 2008
In this tutorial review, the methods available for the selective protection of ribonucleosides are commented on, introducing the reader to the synthetic challenges involved.
Synthesis and surface modification of uniform MFe2O4 (M = Fe, Mn, and Co) nanoparticles with tunable sizes and functionalities
- L. Cabrera, Á. Somoza, J. Marco, C. Serna, M. P. Puerto Morales
- ChemistryJournal of Nanoparticle Research
- 6 June 2012
Cubic monodisperse MFe2O4 ferrite nanoparticles (M = Fe, Co, and Mn) with tunable sizes between 7 and 20 nm and a narrow size distribution have been achieved in a one step synthesis by thermal…
Efficient treatment of breast cancer xenografts with multifunctionalized iron oxide nanoparticles combining magnetic hyperthermia and anti-cancer drug delivery
The therapeutic effects of breast cancer magneticHyperthermia could be strongly enhanced by the combination of MF66 functionalized with N6L and DOX and magnetic hyperthermia and represents a straightforward strategy for translation into the clinical practice when injecting nanoparticles intratumorally.
Multifunctionalized iron oxide nanoparticles for selective drug delivery to CD44-positive cancer cells.
This work presents the synthesis and characterization of novel multifunctionalized iron oxide magnetic nanoparticles (MNPs) with antiCD44 antibody and gemcitabine derivatives, and their application for the selective treatment of CD44-positive cancer cells and shows the selective drug delivery potential of the MNPs.
DNA and aptamer stabilized gold nanoparticles for targeted delivery of anticancer therapeutics.
Modified GNPs loaded with doxorubicin or AZD8055 show significant and increased reduction of cell viability in breast cancer and uveal melanoma cell lines, highlighting that modified GNPs can be functionalized to increase the efficacy of cancer therapeutics and may further reduce toxicity by increasing targeted delivery towards malignant cells.
Antibacterial Activity of DNA-Stabilized Silver Nanoclusters Tuned by Oligonucleotide Sequence.
- S. Javani, Romina Lorca, Alfonso Latorre, C. Flors, A. Cortajarena, Á. Somoza
- BiologyACS applied materials & interfaces
- 15 April 2016
A trimeric structure was prepared containing the sequence that afforded the best antimicrobial activity, which inhibited the growth of Gram-positive and negative bacteria in the submicromolar range.
Targeting autophagy using metallic nanoparticles: a promising strategy for cancer treatment
It is believed that autophagy modulation with nanoparticle-based strategies would acquire clinical relevance in the near future, as a complementary therapy for the treatment of cancers and other diseases.
Discovery of selective ligands for telomeric RNA G-quadruplexes (TERRA) through 19F-NMR based fragment screening.
The first successful application of (19)F-NMR fragment-based screening to identify chemically diverse compounds that bind to an RNA molecule such as TERRA is reported, suggesting a selective recognition of this particular quadruplex topology and that different ligands may recognize specific sites in propeller-like parallel G-quadruplexes.
Modified siRNAs for the study of the PAZ domain.
Chemical modifications aimed at stabilizing the interaction between the 3'-end of siRNAs and the PAZ domain of RISC have been tested for their effect on RNAi activity. Such modifications contribute…