Mechanisms of Photoaging and Cutaneous Photocarcinogenesis, and Photoprotective Strategies with Phytochemicals
- R. Bosch, N. Philips, S. González
- BiologyAntioxidants
- 26 March 2015
The photoprotective strategies to prevent/treat photoaging and photocarcinogenesis include oral or topical agents that act as sunscreens or counteract the effects of UV radiation on DNA, cellular antioxidant balance, signal transduction pathways, immunology and the ECM.
Epigenetic disruption of ribosomal RNA genes and nucleolar architecture in DNA methyltransferase 1 (Dnmt1) deficient cells
- J. Espada, E. Ballestar, M. Esteller
- BiologyNucleic Acids Research
- 13 March 2007
It is shown that human cells lacking DNA methyltransferase 1 (Dnmt1), but not Dnmt33b, have a loss of DNA methylation and an increase in the acetylation level of lysine 16 histone H4 at the rRNA genes.
Human DNA Methyltransferase 1 Is Required for Maintenance of the Histone H3 Modification Pattern*
- J. Espada, E. Ballestar, M. Esteller
- BiologyJournal of Biological Chemistry
- 27 August 2004
It is shown that human cancer cells lacking DNMT1 display at least two important differences with respect to wild type cells: a profound disorganization of nuclear architecture, and an altered pattern of histone H3 modification that results in an increase in the acetylation and a decrease in the dimethylation and trimethylation of lysine 9.
Expression, regulation and clinical relevance of the ATPase inhibitory factor 1 in human cancers
- M. Sánchez-Aragó, L. Formentini, J. Cuezva
- BiologyOncogenesis
- 1 April 2013
It is demonstrated that IF1 is a short-lived protein strongly implicating translation and/or protein stabilization as main drivers of metabolic reprogramming and cell survival in these human cancers.
Apoptosis in the pathogenesis of Nosema ceranae (Microsporidia: Nosematidae) in honey bees (Apis mellifera).
- M. Higes, Á. Juarranz, R. Martín-Hernández
- BiologyEnvironmental Microbiology Reports
- 1 August 2013
The results suggested that N. ceranae prevents apoptosis in epithelial cells of infected ventriculi, a mechanism possible designed to enhance parasite development.
Regulation of SNAIL1 and E-cadherin function by DNMT1 in a DNA methylation-independent context
- J. Espada, H. Peinado, M. Esteller
- BiologyNucleic Acids Research
- 16 August 2011
It is reported that PCNA and DMAP1 domains in the N-terminal region of DNMT1 are sufficient to modulate E-cadherin expression in the absence of noticeable changes in DNA methylation patterns in the gene promoters involved.
CdSe quantum dots for two-photon fluorescence thermal imaging.
- L. M. Maestro, E. Rodríguez, J. G. Solé
- Physics, ChemistryNano letters (Print)
- 9 November 2010
The ability of CdSe quantum dots to image a temperature gradient artificially created in a biocompatible fluid (phosphate-buffered saline) and also their ability to measure an intracellular temperature increase externally induced in a single living cell are demonstrated.
The effect of induced queen replacement on Nosema spp. infection in honey bee (Apis mellifera iberiensis) colonies.
- C. Botías, R. Martín-Hernández, M. Higes
- BiologyEnvironmental Microbiology
- 1 April 2012
Queen replacement resulted in a remarkable decrease in the rates of Nosema infection, comparable with that induced by fumagillin treatment, however, detrimental effects on the overall colony state were observed due to the combined effects of stressors such as the queenless condition, lack of brood and high infection rates.
Microsporidia infection impacts the host cell's cycle and reduces host cell apoptosis
- R. Martín-Hernández, M. Higes, N. Boonham
- BiologyPLoS ONE
- 2 February 2017
This is the first report describing molecular pathways related to parasite-host interactions that are probably intended to ensure the parasite’s survival within the cell.
Morphological criteria to distinguish cell death induced by apoptotic and necrotic treatments
- S. Rello, J. Stockert, Á. Villanueva
- BiologyApoptosis
- 2005
The results indicate that morphological criteria allow to distinguish these cell death mechanisms, and show that the necrotic process occurs in a characteristic sequence (coalescence of membrane bubbles in a single big one that detaches from cells remaining on the substrate).
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